Vaginal Microbiome in Cervical Intraepithelial Neoplasia and Cancer
The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).
Funding Fogarty Program
Emerging Global Leader
Project Information in NIH RePORTER
Vaginal Microbiome in Cervical Intraepithelial Neoplasia and Cancer
Principal Institution
University of Jos
Principal Investigator(s) (PI)
Musa, Jonah
Project Contact Information
Email: drmusaj@yahoo.com
Year(s) Awarded
2019–2024
Country
Nigeria
Collaborators
Northwestern University
Project Description
In absolute numbers, Nigeria is one of the countries with the highest burden and mortality due to invasive cervical cancer with over 53 million women at risk. Available cervical cancer screening by conventional cervical cytology coverage is less than 9%, which is in part responsible for over 14,000 new invasive cervical cancer (ICC) cases and over 8,000 deaths every year. We know that the causative agent of this preventable cancer is a sexually transmissible virus, the high-risk human papillomavirus (HR-HPV), whose persistence leads to cellular transformations progressing to invasive cancer if not detected and treated.
Since these viruses are acquired through high-risk sexual behavior, understanding the microbiome community state types, and the inflammatory biomarkers and epigenetic signatures associated with the HR-HPV in high grades precancerous stages of the cervix and ICC could provide evidence for developing primary interventions and early diagnostic markers for identifying these women in our population.
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