The Impact of HIV on the Breast Cancer Tumor Microenvironment
The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).
Funding Fogarty Program
HIV-associated Noncommunicable Diseases Research at LMIC Institutions
Project Information in NIH RePORTER
The Impact of HIV on the Breast Cancer Tumor Microenvironment
Principal Institution
Fred Hutchinson Cancer Research Center
Principal Investigator(s) (PI)
Menon, Manoj P.
Project Contact Information
Email:
mmenon@fredhutch.org
Year(s) Awarded
2021–2023
Country
Uganda
Project Description
Based at the Uganda Cancer Institute – Fred Hutch Cancer Centre (UCI-FHCC) in Kampala, Uganda, and the Fred Hutch Cancer Research Center in Seattle, Washington, we aim to conduct research to define drivers and actionable effects of HIV and associated immune dysregulation in the tumor niche in breast cancers in women living with HIV (WLWH). We will perform integrated immune profiling and genomic studies to define mechanisms by which persistent HIV and associated immune abnormalities shape the tumor microenvironment (TME) and inhibit tumor immune surveillance and immune control. Our research aims to translate discoveries about HIV-associated immune dysfunction in the TME into testable hypotheses for novel immune-based approaches for the prevention and treatment of breast cancers for WLWH in sub-Saharan Africa.
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