Prevalence and temporal dynamics of clonal mutations associated with the risk of hematological cancer in a cohort of clinically healthy Nigerians
The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).
Funding Fogarty Program
Emerging Global Leader
Project Information in NIH RePORTER
Prevalence and temporal dynamics of clonal mutations associated with the risk of hematological cancer in a cohort of clinically healthy Nigerians
Principal Institution
Nigerian Institute of Medical Research
Principal Investigator(s) (PI)
Oyebola, Kolapo
Project Contact Information
Email:
oyebolakolapo@yahoo.com
Year(s) Awarded
2021-2026
Country
Nigeria
NIH Partners
NHLBI
Project Description
Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related marker of blood cancer and cardiovascular diseases. Early and pre-disease detection of rare somatic mutations associated with CHIP in clinically healthy normal-aging Nigerians is much needed as they could offer important prediction of the risk of developing hematological malignancies and provide information on potential targets of therapeutic interventions. This project will also acquire fundamental skills in error-corrected sequencing, variant analysis and data management critical for my establishment as an independent Africa-based medical geneticist.
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