Full Award: Neonatal imaging as an early marker of neurodevelopment and predictor of cognitive performance in infants exposed to HIV and ART in utero and perinatally

The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).

Funding Fogarty Program

Global Brain Disorders Research

Project Information in NIH RePORTER

Neonatal imaging as an early marker of neurodevelopment and predictor of cognitive performance in infants exposed to HIV and ART in utero and perinatally

Principal Institution

Massachusetts General Hospital

Principal Investigator(s) (PI)

Van Der Kouwe, Andre Jan Willem; Laughton, Barbara; Meintjes, Ernesta Maria

Project Contact Information

Email: andre@nmr.mgh.harvard.edu

Year(s) Awarded

2016-2023

Country

South Africa

Collaborators

University of Cape Town
Stellenbosch University

NIH Partners

NICHD

Project Description

Successful programs for the prevention of mother-to-child transmission (PMTCT) have resulted in a new population of HIV-exposed, uninfected children. Evidence suggests that neurodevelopment is delayed in these children relative to their unexposed peers and that they may be at increased risk of illness and mortality. In this project, we will evaluate the effects of in utero and perinatal exposure to antiretroviral drugs and HIV on the infant brain, using leading-edge neonatal magnetic resonance neuroimaging techniques and neurodevelopmental assessments. The project builds on existing collaboration between the Universities of Stellenbosch and Cape Town and the Massachusetts General Hospital.

Related World Regions / Countries

Sub-Saharan Africa