Dysregulation of the Human Ubiquitin Proteasome System in Pediatric Severe Malarial Anemia
The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).
Funding Fogarty Program
Emerging Global Leader
Project Information in NIH RePORTER
Dysregulation of the Human Ubiquitin Proteasome System in Pediatric Severe Malarial Anemia
Principal Institution
Maseno University
Principal Investigator(s) (PI)
Anyona, Samuel Bonuke
Project Contact Information
Email: sbonuke@gmail.com
Year(s) Awarded
2020-2024
Country
Kenya
Collaborators
University of New Mexico
Project Description
Children living in high transmission regions for
Plasmodium falciparum, the most deadly malaria parasite, suffer from 61% of the malaria deaths, of which 93% occur in Africa. The main cause of severe disease and death in these children is from profoundly low hemoglobin (Hb<5.0g/dL) levels, classified as severe malarial anemia (SMA). This project aims to study the human ubiquitin proteasome system (UPS) which is an important pathway for host-pathogen interactions, yet remains unexplored in human malaria, including in Kenyan children who will be the focus of the studies.
Related World Regions / Countries
Related Global Health Research Topics