A comprehensive whole genome sequence scan for positive selection in southern Africa
The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).
Funding Fogarty Program
Emerging Global Leader
Project Information in NIH RePORTER
A comprehensive whole genome sequence scan for positive selection in southern Africa
Principal Institution
Stellenbosch University
Principal Investigator(s) (PI)
Uren, Caitlin
Project Contact Information
Email:
caitlinu@sun.ac.za
Year(s) Awarded
2023-2026
Country
Botswana; Namibia; South Africa
NIH Partners
NHGRI
Project Description
The influence of positive natural selection in shaping the genomes of southern African populations is largely unknown. Using the most appropriate and accurate statistical method, this study will scan large-scale whole genome sequencing datasets (over 1,000 individuals from approximately five populations) for signals of positive natural selection and characterize the functional importance of identified signals. Ultimately, this study will aim to detect novel positive selection signals that could have a potential impact on various human phenotypes in a largely understudied population.
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