Unravelling the role of gene therapy on spinal disc mediated low back pain
The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).
Funding Fogarty Program
Emerging Global Leader
Project Information in NIH RePORTER
Unravelling the role of gene therapy on spinal disc mediated low back pain
Principal Institution
The Federal University of Technology Akure
Principal Investigator(s) (PI)
Ogunlade, Babatunde
Project Contact Information
Email:
bogunlade@futa.edu.ng
Year(s) Awarded
2024-2029
Country
Nigeria
Project Description
Intervertebral disc degeneration (IVDD) is a multifactorial process regarded as the primary cause of low back pain that exerts an enormous public health burden and disability on millions of individuals with current conservative surgical options having limited treatment efficacy.
This study evaluates the modulating role of gene therapy, an unleveraged therapeutic intervention, on pyroptosis-mediated pathways in a rat model of IVDD progression over 12 weeks. Uncovering the potential of gene therapy as an alternative treatment option for low back pain and its role in pyroptosis proteins aligns with the National Institute of Health’s mission and Fogarty International Center’s vision statements to reduce disease burden and disability, improve health, and extend longevity for all people.
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