Risk for Bone Loss Among Individuals with HIV in a Resource-Limited Environment
The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).
Funding Fogarty Program
International Research Scientist Development Award (IRSDA)
Project Information in NIH RePORTER
Risk for Bone Loss Among Individuals with HIV in a Resource-Limited Environment
Principal Institution
Yale University
Principal Investigator(s) (PI)
Hsieh, Evelyn
Project Contact Information
Email: evelyn.hsieh@yale.edu
Year(s) Awarded
2015–2022
Country
China
Collaborators
Peking Union Medical College Hospital
Beijing You'am Hospital
Longtan Hospital
NIH Partners
NIH Office of the Director (OD)
Project Description
Chronic antiretroviral therapies (ART), especially tenofovir, place individuals with HIV at risk for osteoporosis and associated fractures, which can lead to substantial disability, mortality and health-care costs. In China, as in many other low- and middle-income countries, a tenofovir-based regimen has now been adopted as first-line therapy due to its greater potency, tolerability, and cost-effectiveness; however infrastructure to diagnose and manage osteoporosis and fracture remains severely limited. Our proposal utilizes dual-energy x-ray absorptiometry, the gold standard for bone mineral density (BMD) assessment to identify subgroups of patients at highest risk for bone loss in a longitudinal cohort of Chinese patients with HIV on tenofovir-lamivudine-efavirenz; compares the ability of quantitative ultrasound, a low-cost method of measuring BMD, to identify the same group of high risk individuals; and employs mixed-methods approaches to identify potential targeted interventions for fracture risk reduction that can be incorporated into the long-term care of patients with HIV in resource-limited settings.
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